Selena, a Bloodline heir with no heartbeat since birth, is arranged by her adoptive father Victor to marry Prince Lucien. At the wedding, the Wolf King Cain bursts in to seize the marriage; it is within his arms that Selena hears her own heartbeat for the first time. She initially believes Cain is the one who will rescue her from the Bloodline's prison, but soon discovers that an ancient prophecy dictates that the Wolf King must personally pierce the heart of the Moonblood Bride on the Blood Moon night to save the werewolf race, which is being devoured by Silver Poison. The two fall in love amidst desire, suspicion, and blood-bound vows; yet, Cain ultimately kills Selena on the altar. Seven days later, Selena is resurrected as the Queen of the Bloodline and locks Cain near her bed to seek revenge. As the truth emerges—that her adoptive father Victor murdered her parents and had long suppressed her power with medication—Selena personally ends the old dominion, breaks the destined blood bond, and chooses Cain once again after Cain destroys his magical powers to repent and atone.